CLYRA TECHNOLOGY
(Clyrasept™)
Advanced Oxidation Reaction
Clyra Medical Technologies products feature a potent and broad-spectrum antibacterial, antifungal & antiviral oxidation system. With no known acquired resistance capability we deliver it on demand and in a proper dose so that it is safe and effective.
The tailored ion concentration present in the Clyra copper-iodine technology creates an oxidative environment.
This oxidative environment is able to neutralize pathogens such as. bacteria, yeast, fungi, viruses, fungi, spores and spores, and antibiotic-resistant strains of bacteria.
Antimicrobial activity of iodine and copper has been demonstrated in numerous studies worldwide.¹⁻⁴
Benefits of Clyra's copper-iodine technology
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Extremely high efficacy. 99.9999% kill rate againstbacteria, yeast, fungi, viruses, fungi, spores and spores, and antibiotic-resistant strains of bacteria .⁵⁻⁸
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No known microbial resistance.
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High and sustained antimicrobial control up to 3 days.⁵
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Effective in preventing biofilms. 2.0-2.5 log reduction.⁹
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Safe / non-irritating / non-toxic / non-sensitizing (met acceptance criteria of biocompatibility testing (ISO 10993 standard).¹⁰⁻¹⁴
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Compatible with wound tissue.
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Non-staining / colorless / odorless.
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Balanced pH for wound healing.
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Superior and extended wound odor control.
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Environmentally friendly.
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Storage at room temperature.
References
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Cooper RA. Iodine revisited. Int Wound J 2007; 00:1–4. DOI: 10.1111/j.1742-481X.2007.00314.x.
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Gadi Borkow and Jeffrey Gabbay. Copper as a Biocidal Tool. Current Medicinal Chemistry, 2005, 12, 2163-2175.
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Carolina Falcón García, Martin Kretschmer, Carlos N. Lozano-Andrade, Markus Schönleitner, Anna Dragoŝ, Ákos T. Kovács and Oliver Lieleg. Metal ions weaken the hydrophobicity and antibiotic resistance of Bacillus subtilis NCIB 3610 biofilms. npj Biofilms Microbiomes 6, 1 (2020). https://doi.org/10.1038/s41522-019-0111-8.
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Jonathan Baker, Sutthirat Sitthisak, Mrittika Sengupta, Miranda Johnson, R. K. Jayaswal, and Julie A. Morrissey. Copper Stress Induces a Global Stress Response in Staphylococcus aureus and Represses sae and agr Expression and Biofilm Formation. Applied and Environmental Microbiology, 2010, p. 150–160. doi:10.1128/AEM.02268-09.
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GLP Time Kill Study. Nelson Laboratories. Study Numbers: 913680-S01 (Bacteria) and 1012993-S01 (Fungus). 2016-2018.
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Antimicrobial Effectiveness Test (AET) (USP<51>). KLM Labs.
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In vitro efficacy testing of Clyra Irrigation Solution for Coronavirus (Covid-19) inactivation. SLP-0401-0003. Galveston National Laboratory Preclinical Studies Core. The University of Texas Medical Branch.
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Time kill testing of Clyra solution against C. acnes. Biolargo Water Laboratory. University of Alberta.
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GLP Pig study to assess the anti-biofilm and antimicrobial activity. BRIDGE PTS. Study Number: GLP-170217. 2017.
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GLP Cytotoxicity by Agar Overlay. Nelson Laboratories. Report number: 1012989-S01. 2018.
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GLP Direct Primary Skin Irritation Test - ISO Abraded Method. Nelson Laboratories. Report: 19-00374-G1. Report Number: NL# 1144568. 2019.
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GLP Materials Mediated Rabbit Pyrogen (No Extraction). Nelson Laboratories. Test code: 900770.3. Report Number: 118088. 2018.
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GLP Guinea Pig Maximization Sensitization Test (Method for Liquid Test Article). Nelson Laboratories. Test code: 900854.1. Report Number: 122860. 2018.
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Toxicological Risk Assessment (Chronic and sub-chronic systemic toxicity prolonged contact >24 hours < 30 days). Nelson Laboratories. Project numbers: SC19011-DER01 and SC19011-DER01.1.
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GLP wound healing study in a full-thickness porcine dermal wound model up to 28 days. BRIDGE PTS. Study Number: GLP-190510. 2019.