CLYRA TECHNOLOGY

Advanced Oxidation Reaction

Clyra Medical Technologies products feature a potent and broad-spectrum antibacterial, antifungal & antiviral oxidation system.  With no known acquired resistance capability we deliver it on demand and in a proper dose so that it is safe and effective.

The tailored ion concentration present in the Clyra copper-iodine technology creates an oxidative environment.

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This oxidative environment is able to  neutralize pathogens such as viruses, fungi and bacteria.

It is also effective against biofilms.

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Antimicrobial activity of iodine and copper has been demonstrated in numerous studies worldwide.¹⁻⁴

Benefits of Clyra's copper-iodine technology

  • Extremely high efficacy. 99.999% kill rate against bacteria, viruses and fungi.⁵⁻⁸

  • No known microbial resistance.

  • High and sustained antimicrobial control up to 3 days.⁵

  • Effective against biofilms. 2.0-2.5 log reduction.⁹

  • Safe / non-irritating / non-toxic / non-sensitizing (met acceptance criteria of biocompatibility testing (ISO 10993 standard).¹⁰⁻¹⁴

  • Compatible with wound tissue.

  • Non-staining / colorless / odorless.

  • Balanced pH for wound healing.

  • Wound odor control.

  • Environmentally friendly.

  • Storage at room temperature.

References

  1. Cooper RA. Iodine revisited. Int Wound J 2007; 00:1–4. DOI: 10.1111/j.1742-481X.2007.00314.x.

  2. Gadi Borkow and Jeffrey Gabbay. Copper as a Biocidal Tool. Current Medicinal Chemistry, 2005, 12, 2163-2175.

  3. Carolina Falcón García, Martin Kretschmer, Carlos N. Lozano-Andrade, Markus Schönleitner, Anna Dragoŝ, Ákos T. Kovács and Oliver Lieleg. Metal ions weaken the hydrophobicity and antibiotic resistance of Bacillus subtilis NCIB 3610 biofilms. npj Biofilms Microbiomes 6, 1 (2020). https://doi.org/10.1038/s41522-019-0111-8.

  4. Jonathan Baker, Sutthirat Sitthisak, Mrittika Sengupta, Miranda Johnson, R. K. Jayaswal, and Julie A. Morrissey. Copper Stress Induces a Global Stress Response in Staphylococcus aureus and Represses sae and agr Expression and Biofilm Formation. Applied and Environmental Microbiology, 2010, p. 150–160. doi:10.1128/AEM.02268-09.

  5. GLP Time Kill Study. Nelson Laboratories. Study Numbers:  913680-S01 (Bacteria) and 1012993-S01 (Fungus). 2016-2018.

  6. Antimicrobial Effectiveness Test (AET) (USP<51>). KLM Labs.

  7. In vitro efficacy testing of Clyra Irrigation Solution for Coronavirus (Covid-19) inactivation. SLP-0401-0003. Galveston National Laboratory Preclinical Studies Core. The University of Texas Medical Branch.

  8. Time kill testing of Clyra solution against C. acnes. Biolargo Water Laboratory. University of Alberta.

  9. GLP Pig study to assess the anti-biofilm and antimicrobial activity. BRIDGE PTS. Study Number: GLP-170217. 2017.

  10. GLP Cytotoxicity by Agar Overlay. Nelson Laboratories. Report number: 1012989-S01. 2018.

  11. GLP Direct Primary Skin Irritation Test - ISO Abraded Method. Nelson Laboratories. Report:  19-00374-G1. Report Number:  NL# 1144568. 2019.

  12. GLP Materials Mediated Rabbit Pyrogen (No Extraction). Nelson Laboratories. Test code: 900770.3. Report Number: 118088. 2018.

  13. GLP Guinea Pig Maximization Sensitization Test (Method for Liquid Test Article). Nelson Laboratories. Test code: 900854.1. Report Number: 122860. 2018.

  14. Toxicological Risk Assessment (Chronic and sub-chronic systemic toxicity prolonged contact >24 hours < 30 days). Nelson Laboratories. Project numbers: SC19011-DER01 and SC19011-DER01.1.

  15. GLP wound healing study in a full-thickness porcine dermal wound model up to 28 days. BRIDGE PTS. Study Number: GLP-190510. 2019.